Biopolymers and cell. 1986. Volume 2. № 4. 200 - 206
V. K. Savchenko, L. S. Mikhalevich, L. M. Kukushkina
ASSOCIATIVE CLONE SELECTION OF CHINESE HAMSTER CELLS FOR A COMPLEX OF QUANTITATIVE CHARACTERS
Summary
Associative clone selection for a complex of quantitative characters was carried out in populations of cultivated cells. Two hypotetraploid cell populations of Chinese hamster of plus- and minus-direction of selection were studied. The possibility of preserving relatively stable caryotypic structure of polyploid cell populations of spontaneous origin during 20 cell passages. An entropy index was used as a measure of caryotypic heterogeneity and general structure indefinitness of genetic systems — cell populations. A definite correlation between an increase in the genome number in a cell and a change in a set of quantitative characters was determined.