Biopolymers and cell. 1986. Volume 2. № 4. 212 - 215
E. R. Zabarovsky, I. V. Starkov, V. N. Mordovtseu, L. L. Kisselev
EVALUATION OF PROTO-ONCOGENE EXPRESSION IN EPIDERMIS OF PSORIATIC PATIENTS
Summary
RNAs isolated from the epidermis of psoriatic patients were dot-blot hybridized with viral oncogenes (fos, myc, src, erbB, Ki-ras and abl). The RNAs from epidermis of the nonpsoriatic patient and from aorta epithelium were used for comparison. The data show that the expression of protooncogenes Ki-ras, abl, fos and myc significantly increased in psoriatic plaques. These results open new ways for the analysis of etiology of psoriasis and its cure.