Biopolymers and cell. 1989. Volume 5. № 4. 30 - 37

G. M. Suboch, Yu. A. Sprizhitsky

STATISTICAL SIGNIFICANCE OF THE OCCURRENCE OF SOME COMPLEX NUCLEOTIDE COMBINATIONS: COMPARISON OF THE DNA MODELS

Summary

    A scheme for modeling of the DNA chain as a sequence of the nucleotide runs of different length is presented. The advantages of such a method and range of its application are discussed. A procedure is suggested to estimate statistical significance of occurrence of some complex sequence structures in DNA by the Monte-Carlo method. It uses a bootstrap algorithm and necessitates comparatively small number of calculations. Three different models, used to derive such estimations of the frequencies of homopurine-homopyrimidine mirror repeats in the DNA of phage K and rodentia noncoding regions are compared.