Biopolymers and cell. 1991. Volume 7. № 6. 15 - 32

SUKHODUB L. F.

The Possibilities of the Soft-Ionization Mass-Spectrometry in the Molecular-Biological Studies

Summary

    The results which demonstrate the possibilities of the soft-ionization mass-spectrometry (SI-MS) for molecular-biological studies in two direction—thermodynamic and analyti¬cal-structural are given. The method of the temperature-dependent field ionization mass-spectrometry which was the first time used for measuring of the thermodynamic characteristics of the number biological associates: Watson-Crick, mispairing and other base pairs, «aminoacid-base» complexes, hydrates of the bases and their pairs are described. The possibilities of the SI-MS for study of the hydrolysis the antitumour drugs in the physiological solutions and adducts of their interactions with DNA are shown.