Biopolymers and cell. 1991. Volume 7. № 6. 96 - 99

SHAVLOVSKY G. M., STENCHUK N. N., KSHANOVSKAYA B. V.

The Influence of the Regulatory Mutation in the RIB1 Locus on the Riboflavin Biosynthesis in Pichia guilliermondii

Summary

    The ribl-86 mutant of P. guilliermondii in which riboflavin auxotrophy is suppressed by mutation ribSl, but not by rib80 was selected. Double ribl-86 ribSl mutant is characteri¬zed by low GTP-cyclohydrolase activity. The enzyme synthesis is faintly regulated by iron. It is supposed that ribl-86 mutation is localized in the promoter region of RIB1 ge¬ne which codes for GTP-cyclohydrolase.