Biopolymers and cell. 1994. Volume 10. № 5. 5 - 30

A. P. Kukharenko, A. D. Shved

HIV-1 REGULATORY GENES AND THEIR ROLE IN THE VIRAL GENOME REALIZATION

Summary

    Review summarises recent data related to the role and function of the auxiliary regulatory genes nef, vpu, vpr, vif, tat and rev of HIV-1 in viral replication. We devoted attention rather to the tat, rev, nef and their products as to the main regulators of the realization of HIV-1 lentiviral genome. Possible mechanisms of influence of these viral products on proviral activity in couple with host-cellular factors are considered. Cytopathophysiological effections of some viral regulatory proteins upon HIV-1 persistention of permissible cells are also shortly reviewed.