Biopolymers and cell. 1994. Volume 10. № 6. 98 - 105

V. V. Frolkis, V. A. Kordyum, S. N. Novikova, L. N. Bogatskaya, D. M. Irodov, L. I. Likhacheva, R. I. Potapenko, T. G. Mozguhina, M. K. Bitner

THE INFLUENCE OF THE IMPLANTED CLONING HUMAN'S apoAl GENE ON THE DEVELOPMENT OF RABBIT' HYPERCHOLESTERINEMY

Summary

    The effect of the implanted cloning human's apoAl gene on the dynamic of rabbit's lipid and lipoproteid metabolism in conditions of development of experimental hypercholesterinemy was investigated. The implantation of apoAl gene results in the appearance of human apolipoprotein Al in the blood of experimental animals, the changes in the content of cholesterine and it's shifts in different fractions of LP, the changes in the ratio of different classes of LP in favour Chs-HDLP and HDLP. It is supposed that transfection of apoAl human's gene and it's transitory expression leads not only to the biosynthesis of respective protein but also to a change in the work of total genome via gene-regulatory mechanisms.