Biopolymers and cell. 1995; 11 (1): 81 - 86

INVESTIGATION OF AUTOANTIBODIES DIRECTED AGAINST TISSUE-SPECIFIC MYOCARDIAL ANTIGENS IN DILATED CARDIOMYOPATHY

L. L. Sidorik, N. V. Rodnin, V. I. Bobyk, D. V. Ryabenko, A. V. Veberov, T. Yu. Tkachenko, G. Kh. Matsuka

The autoantibodies directed against actin and tnyosine have been detected in the blood sera of patients with dilated cardiomyopathy (DCMP) at the level that was sufficiently higher than in healthy donors. While comparing of the immunogeneicity of these pro¬teins we have stated that myosine from affected by DCMP myocardium have been more immunogenic then from normal one. In the case of actin the immunogeneicity have been higher for the protein from normal myocard. The investigations of actin by limited proteolysis may suggest that the differencies in immune properties are not connected with primary structure but with structures of higher levels.