Biopolymers and cell. 1995; 11 (3-4): 5 - 23

 

 

MOLECULAR-AND GENETIC ASPECTS OF DUCHENNE MUSCULAR DYSTROPHY

 

V. I. Grishko. L. A. Livshits

 

Duchene muscular dystrophy (DMD) is the X-linked recessive disorder resulting in pro¬gressive degeneration of the muscle. It affects about I in 3500 male children. Present reviw represents the modern date about DMD gene structure and localization the spectrum of mutations of DMD gene ,and characteristics of its protein product — dystrophine. The me¬thodology of DNA diagnostic and approaches to the therapy of DMD are discussed.