Biopolymers and cell. 1995; 11 (5): 56 - 60

ANTIVIRAL ACTIVITY OF TRIMERIC 2',5'-OLIGOADENYLIC ACID AND SOME OF ITS ANALOGUES

Z. Yu. Tkachuk, L. I. Semernikova, V. V. Tkachuk, L. M. Resholko, 1. A. Mikhailopulo, G. K.h. Matsuka

The authors have studied the antiviral effect of 2',5'-trioligoadenylate and of its de¬rivatives using several model cell culture systems and viruses: L929 murinc fibroblast cells infected by vaccine virus, established testicular piglet cells inoculated by Aueszki disease virus (ADV) (strain BUK-628), and the same culture infected with Purdue-115 strain (reference strains of transmissible gastroenteritis virus (TGEV)). So, it is possible to suppose that both 2',5'-trioligoadenylate and its derivative are perspective antiviral preparations acting against DNA- and RNA-containing viruses.