Biopolymers and cell. 1996; 12 (2): 7 - 19

Mobile genetic elements in mutagenic process, recombination and malignization of human cells

L. L. Lukash, L. P. Slivachko, K. V. Kostetskaya

Mutagenesis is known as the major stage of the complicated process of malignization. There are a lot of data in support of this idea, for example, all known cancerogenes are mutagtnes. During several years microsatellite DNA instability was recognized as important trait of tumours. In this paper we reviewed the contribution of mobile genetic elements (human. Alu repetitive sequences) in appearance of heritable and somatic diseases, includingmalignization.Localizingin«/V)tspot» of mutagenic andreconibinationevents Alu sequences appear to be genetic markers for the estimation of human genome instability.