Biopolymers and cell. 1997; 13 (1): 63 - 69

The antioxidant-genoprotective mechanism of the action of the preparation «Mumiyo-Vitas»

E. L. Levitsky, Yu. I. Cubskiy, R. G. Primak, A. G. Goryushko, A. N. Marchenko, I. E. Vistunova

The protective effect as regards the liver nuclear chromatin of the drug preparation «Mumiyo-Vitas» in condition of genotoxic action of the chlorophose is revealed. This effect is realized in conditions of profilactic intraperitoneal way of the preparation injection to the experimental animals (thrice-repeated before 36, 24 and 0,5 h the poison in dose 240 mg/kg of the body mass) and related to the antioxidant action as regards the lipids chromatin peroxidation processes. The antioxidant-genoprotective effect of the preparation is more expressed as regards the transcriptionally active chromatin fraction and is correlated to the mortality reduction of the experimental animals. In the realization of this effect mainly the c chromatin phosphatidylcholin lipids and DNA take part in.