Biopolymers and cell. 1998; 14 (6): 534 - 539

Modulatory effect of aluminium and its complex with quercclin on muscle contractile regulatorty mechanisms

T. L. Davidovskaya, K. 1. Bogutska, P. G, Minc/wnko, N. S. Miroshnichenko

It was shown tliat the guercetin decreases permeability of plasm?/ membrane of smooth muscle of large intestine from guinea pig for calcium ions and does not influence on intracellular depots of sac!'. cations. Aluminium increases the amplitude of kalium-induced contractions, while the amplitude of caffeine-induced replies stays without changes. Aluminium complex with guercetin can penetrate to myocytcs due to solubility in lipid phase of plasma membrane and changes Ca release from sarcoplasmic reticulum. It has been fou.ni! that aluminium can influence on the structural changes of actr>~ myosin complex of skeletal muscle.