Biopolymers and cell. 1999; 15 (2): 103 - 108

Different models of the diabetes mellitus in experimental research on animals

T. G. Tytok, A. A. Evseenko, F. Adjamiyan, V. A. Kordyum

This review describe the established mod,e!s of the diabetes in rodents. They mver different forms of the disease concerned with the natural mutations occurred, with genetic engineering mani¬pulations and with the induction using different chemicals agents like as alloksan and streptozotocin (STZ). It was shown that mice response to the subdiabetogemc STZ doses is influenced !>y animal age. It was also shown the subsequent injection sensibilizes mice response.