Biopolymers and cell. 1999; 15 (4): 314 - 318

The effect of trimeric 2',5'-oligoadenylic acid and its epoxyderivative on the human immunodeficiency virus reproduction and retroviruses reverse transcriptase activity

Z. Yu. Tkachuk, S. L. Rybalko, L. I. Semernikova, V. V. Tkachuk, M. P. Zavelevich, L. V. Tkachuk, I. O. Mikhailopulo, G. Kh. Matsuka

The study of the effect of trimeric 2',5'-oligoadenytic acid (2',5'ApApA) and its epoxyderivative (2',5'-A2(KAA)) on both human immunodeficiency virus (HIV-1) reproduction and retro-viruses reverse transcriptase activity was conducted. 2',5'-oligo-adenylates were shown to suppress HIV-1 reproduction in case of their pre-incubation with the lymphoblastoid cells of MT-4 line. The possible mechanisms of antivirial action of 2' ,5'-oligoadenylates were under investigation, in particular, the interferonogenic effect of the substances was examined. 2',5'ApApA and 2',5'-A2(RAA) were shown to increase amounts of interferon in cells two and four-fold respectively compared to control. The inhibitory effect of 2',5'-oligoadenylates on activity of endogenous and exogenous retroviruses reverse transcriptase was demonstrated. The trimeric 2',5'-oligoadenylic acid and its epoxyderivative may be used against HIV infection.