Biopolymers and cell. 2000; 16 (1): 5 - 15

Biological activity of lipopolysaccharides of gram-negative bacteria

E. L. Zdorovenko, V. K. Pozur, N. E. Kucherenko

Lipopolysaccharides are the main component of gram-negative bacteria's cell wall. The amphipatic molecule of LPS consists of lipid A, core oligosacchar hages to synthesize of proinflammatory (such as tumor necrosis factor, interleukins: IL-l, IL-6, IL-8) and antiinflammatory cytokines (interleukin-10), nitric oxide, antibodies, complement activation, antitumor activity. Thereto lipopolysaccharides own therapeutical effects. They (or some their structural compoiients) are successfull in the treatment of human's cancer, septic shock.