Biopolymers and cell. 2000; 16 (2): 145 - 152

Interaction of cyanine dyes with nucleic acids. 10. Synthesis and spectral properties of novel benzothiazol-4-[2,6-dimethylpyridinium] raonomethyne cyanine dyes

D. V. Krivorotenko, V. B. Kovalska, S. M. Yarmoluk

A number of new derivatives of 2,6-dimcthyl-4-(3-methyl-3H-benzothiazol-2-ilidenmethyl)- 1-alkyl-pyridinium perchlorate have been synthesized to develop novel fluorescent dyes for the nucleic acids detection. Spectral properties of the synthesized dyes, their complexes with nucleic acids and also in the presence of protein have been studied. The influence of different functional groups on fluorescent properties of the novel cyanine dyes and their nucleic acids complexes have been investigated.