Biopolymers and cell. 2000; 16 (4): 270 - 274

Genotoxical effects of ribonuclease in vivo

O. N. Ilinskaya, H. Fret

The toxic and genotoxic effects of Bacillus intermedius ribonuclease at high concentrations have been established using somatic mutation and recombination test (SMART) with Drosophila melanogaster. It has been shown that ribonuclease induces gene mutations detected as single spots of mutant hairs of mwh (multiple wing hairs) phenotype on the wing blade, and leads to the morphological alterations of the Drosophila eyes, in particular to the lysis of a part of facets.