Biopolymers and cell. 2000; 16 (5): 409 - 412

Vitality of cells in culture after combined exposure to heavy metals and radiation

T. N. Dudchenko, G. I. Lavrenchuk, Jo. I. Serkiz, V. A. Zinchenko

Combined influence of middleeffective concentrations of heavy metals (Pb, Ba, Cr, Ni, Cu) and irradiasion by X-rays in LD-50 dose on the indices of vitality of L-cells in culture has been investigated. Kinetic changes of indices are specific for different elements and depend on the level of cellular growth. It was shown that combined exposure to Cr, Pb and radiation on the level of intense cellular growth manifested sinergic or adaptative influence (it decreased growth of cells population, the mitotic index and increased the number of gigantic cells). Cu causes the contrary effect. Pb and Ba increase the mitotic index and the numberof gigantic cells on the stationary growth level.