Biopolymers and cell. 2001; 17 (4): 325 - 330

Preparative synthesis and some properties of deoxyribosylurea, the product of DNA oxidative degradation

I. Y. Dubey, L. V. Dubey

An efficient method for the preparation of 2'-deoxyribosylurea is proposed that includes the oxidation of 5'-O-protected thymidine with potassium permanganate and alkaline hydrolysis of int¬ermediate thymidine glycol. The possibility of detection of urea residues in oligonucleotides has been studied.