Biopolymers and cell. 2001; 17 (5): 411 - 416

 

 

Influence of 2', 5' oligoadenylates and theirs analogues on the cyclic nucleotides level in vivo and in vitro

 

Z. Yu. Tkachuk, V. V. Tkuchuk, L. V. Tkachuk, L. 1. Semernikova, G. Kh. Matsuka

 

It was demonstrated that 2', 5' A analogues, when introduced to organs and tissues in animals, influenced the concentration of cAMP but not cGMP. The effect depends on the concentration and, therefore, one can employ the method of testing cAMP to determine the specific action of 2', 5' A analogues, which could be used at organ transplantation and allergy.