Biopolymers and cell. 2002; 18 (2): 155 - 160

Carbon source regulation of the alcohol oxidase promoter in mutants of the methylotrophic yeast Hansenula polymorpha impaired in catabolite repression

O. G. Stasyk, O. V. Stasyk, A. A. Sibirny

Carbon source regulation of the alcohol oxidase and heterologous glucose oxidase synthesis in mutants of the methylotrophic yeast Hansenula polymorpha impaired in catabolite repression was ana¬lyzed. It was shown that the mutations causing the enzymes oversynthesis in glucose medium are specific in respect to substrate regulation of the alcohol oxidase promoter. The mutants isolated are promising hosts for production of foreign proteins.