Biopolymers and cell. 2002; 18 (4): 267 - 271

 

 

Interaction of recipient genome and transgenes in eukaryoles. Extrachromosomal transgenes

 

K. V. Krysan, A. P. Solomko

 

Two forms of transgenes are known — integrated into the host genome and extrachromosomal. Although the integrated transgenes are more widespread, the extrachromosomal ones are more inte¬resting and promising for biotechnology and biomedicine. At the same time, the mechanisms determining the fate of the introduced DNA molecule, have not been studied entirely. In this review we discuss these mechanisms and analyze the extrachromosomal trans¬genes of different origin.