Biopolymers and cell. 2003; 19 (2): 196 - 201

Inhibitors of cyclin-dependent kinases. Synthesis of combinatorial libraries of 3-phenoxy-7-hydroxy-8-alkylaminomethylchromone derivatives and study on their anticancer activity

V. V. Arkhipov, A. O. Prikhod'ko, A. G. Golub, V. P. Khilya, S. M. Yarmoluk

Cyclin-dependent kinases (CDK) play an important role in the cell cycle regulation. CDK are used as targets in a search for anticancer drugs. This study was aimed at the synthesis of 3-aryloxy-7-hydroxy-8-alkylaminomethylchromone derivatives, potential inhibitors of CDK. The antitumor activity of the compounds synthesyzed has been tested using 60 human tumor cell lines. 4 of the compounds tested have been revealed to inhibit the tumor cells proliferation.