Biopolymers and cell. 2003; 19 (3): 281 - 286

Composite bioregulators on the base of phenazine-1-carboxilic acid and 6-azauracil derivatives. Synthesis and structural characteristics

L. H. Palchykovs'ka, M. O. Platonov, I. V. Alexeeva, A. D. Shved

On the base of phenazine-1-carboxilic acid and 6-azauracil derivatives a number of composites have been constructed and synthesized. The structure of above mentioned compounds have been confirmed by UV and H NMR spectra. The functionally important features of these composites structure have been established by nonempirical (ab initio) quantum-chemical conformation analysis at the level of HF/6-31G* theory. It has been revealed that the length, position and composition of the domain connecting linkers influence the formation of compact or loosened «folding» structure of newly synthesized compounds. These two types of structure affect the polymerase complex in a different manner.