Biopolymers and cell. 2003; 19 (6): 473 - 491

Our «Shagreen leather* is our problem. And we have to solve it. 3. A missing link

V. A. Kordyum

The idea that genomes of multi-cellular organisms, including human, are not informatively isolated but united into a common informational space is being developed. Such unification is performed through formation of out-chromosomal DNA, its release from cells, absorption by other cells (or direct transfer from cell to cell) and further selective inclusion into their genomes. The common informational space of organism is a special and exceptionally effective mechanism of the resistance to mutational pressure.