Biopolymers and cell. Volume 20. 1-2. 93-105.


L. L. Lukash


The regulation of a variability of somatic mammalian cell genome under the influence of exogeneous biological factors




The investigations are reviewed here demonstrate that biological factors of the environment induce mutations through the regulatoric informational influence on cellular systems maintaining genetic stability: replication, recombination, reparation. Among the biological factors which become the genome unstable mobile genetic elements and oncogenic viruses which induce tumorigenic transformation are distinguished. It is supposed that change of the programms of gene expression during the differentiation of stem cells to specialized ones is accompanied by the inclusion the mutation and the recombination processes.