Biopolymers and cell. Volume 20. № 3. 255-258.

I. G. Kostenko, E. V. Zhuravel, G. V. Panasenko, V. P. Shirobokov

Genetic determination of dissociation process of poliovirus type III

Summary

The variants of a vaccine virus strain of a poliomyelitis type III have been proved to occur in the course of reproduction in cell culture, and have differences in nucleotide sequences of a gene VP1. It has been demonstrated, that in variant A_bent+ the nucleotide adenine occupies position 2900, and in variant A_bent-  - guanine. Accordingly, in the structure of protein VP1 an aspartic acid replaces asparagines in position 142, the former influencing the charge and conformation of virion surface proteins.