Biopolymers and cell. Volume 20. № 4. 435-439.

I. V. Alexeeva, L. I. Palchikovskaya, L. N. Nosach, L. S. Usenko, V. L. Zhovnovataya, N. S. Dyachenko

The glycosilic analogues of 6-aza-cytidine: synthesis and antiviral activity

Summary

A number of N1-glycopyranosyl and N1-glycofuranosyl 6-azacytidine analogues were synthesized by one-step «silylic condensation» method. Antiadenovirus activity of these compounds in comparison with parent 6-azacytidine was studied. Preserving D-ribofuranosylic fragment in the analog molecule has been shown necessary for this biological activity. Commutation of this sugar moiety into D-xylose, D-glucose, L-arabinose or even commutation of D-ribofuranosylic fragment into ribopyrano ring in 6-azacytidine molecule leads to the loss in antiadenovirus activity.