Biopolymers and cell. 2005; 21 (1): 3 - 11

Molecular-genetic mechanisms of neuroonthogenesis

V. I. Tsymbalyuk, V. M. Semenova, V. V. Medvedev

The authors present the current scientific data on molecular-genetic mechanisms of neurogenesis, propose a schematic interpretation of gradual differentiation of neuronal cells during the complication of inter-neuronal links, review the data on the onthogenetical role of neuronal stem progenitors and consider the microembrional interpretation of topological reconstruction of neuronal networks during the generation of memory's engrammes.

Key words: neuronal induction, signalling transduction, genetic expression, transcription homeodomen factors, differentiation and determination, growth factors, neuronal stem cell.