Biopolymers and cell. 2006; 22 (6): 475 - 479

Study of biological activity of some 4-S-derivatives of quinoline

V. I. Gencheva, L. A. Omelyanchik, D. M. Fedoryak, A. A. Brazhko, M. P. Zavgorodny

The biological action of (8-methoxy-2-methylquinoline-4-ilthio)-carboxylic acids was studied on the model of acute toxic hepatitis. The most expressed membrane stabilizing effect was observed for β-(8-methoxy-2-methylquinoline-4-ilthio) lactic acid which normalizes the level of enzymic activity and protein synthetic function of a liver. The investigated compounds are shown as perspective potential hepatoprotectors.

Key words: 4-S-derivatives of quinoline, membrane stabilizers, hepatoprotectors.