Biopolymers and cell. 2008; 24 (1): 78 - 81

Influence of human apolipoprotein A-1 transgene injection on level of cholesterol and morphology of tissues of rabbits on cholesterol diet

Iu. M. Gilchuk, O. K. Toporova, S. M. Novikova, V. A. Kordium

It has been shown that repetitive injection of plasmid DNA, containing human apolipoprotein A-1 (apoA-1) gene, in the complex with polyethylenimine into the liver parenchyma of cholesterol-rich diet rabbits influenced cholesterol concentration in animal blood and liver and morphology of vessel tissues. Thus, apoA-1 injected animals were shown not to reveal the increase in total cholesterol concentration in blood and morphology alteration of liver and vessel tissues, specific for atherosclerosis in cholesterol-fed rabbits. The data obtained reveal that human apoA-1 transgene injection might suppress experimental atherosclerosis in cholesterol-fed rabbits.

Keywords: apolipoprotein A-1, atherosclerosis, transgene.