Biopolymers and cell. 2009; 25 (1): 50 - 55

Analysis of molecular features of the ukrainian isolates of hiv-1

N. S. Pukish, A. M. Shcherbinska, N. O. Babij, V. P. Polishchuk

National Taras Shevchenko University of Kyiv,  64, Volodymyrska Str, Kyiv, Ukraine  01033 

Ukrainian center for AIDS prevention, 5 Mykola Amosov str, Kyiv, Ukraine,  03038  

Analysis of HIV-1 genome in the region of pol gene was performed by sequencing virus genome using 64 samples of blood from HIV-infected persons. Subtype a HIV-1 revealed to be dominating among investigated samples and a great number of samples belonged to a circulating recombinant forms of HIV-1. Analysis of mutations showed only one mutation connected with development of HIV-1 resistance to antiretroviral treatment. Most samples in- cluded polymorphic substitutions of nucleotides in the virus genome region studied.

Keywords: human immunodeficiency virus 1, polymorphic substitutions, resistance mutations, recombinant forms of HIV-1, subtype of HIV-1.