Biopolymers and cell. 2009; 25 (2): 110 - 114

The research of neurospecific proteins and lysosomal peptidehydrolases in frontal neocortex during forming conditioned reaction of active avoiding of rats

A. L. Drozdov, V. I. Chorna¹, O. S. Koshelev, O. K. Vyatkin

Dnipropetrovsk State Medical Academy 9 Dzerzhinsky Street, Dnipropetrovsk, Ukraine, 49600
¹National Dnipropetrovsk University 13, prov. Nauchnyy, Dnipropetrovsk, Ukraine, 49050

Dynamics of the activity of neuronal cell adhesion molecule (NCAM) and lysosomal cysteine cathepsins B, L, H was researched in frontal neocortex of rat brain during forming a conditioned reaction of active avoiding. The quantitative estimation of NCAM content in the neocortex membrane fraction was carried on by ELISA in 3, 7, 14 and 21 days after starting animals’ training. The dynamics correlation between the NCAM content increasing and cysteine cathepsins activity was obtained, especially for aminopeptidase cathepsin H during the process of memory engram forming in frontal neocortex of rat brain.

Keywords: NCAM, cysteine cathepsins, learning, memory.