Biopolymers and cell. 2009; 25 (6): 476 - 483
Semi-quantitative model of the gating of KcsA ion channel. 2. Dynamic self-organization model of the gating
V. N. Kharkyanen, S. O. Yesylevskyy, N. M. Berezetskaya, C. Boiteux1, Ch. Ramseyer1
Institute of Physics of National Academy of Sciences of Ukraine 46, Prospect Nauky, Kyiv, Ukraine, 03680
1UMR CNRS 6624, Faculte des Sciences et Techniques, Universite de Franche-Comte 16 route de Gray, La Bouloie, 25030 Besancon Cedex, France
The aim of this series of papers is to develop the semi-quantitative theory of the gating of KcsA channel. Methods. For this purpose available structural and electrophysiological data and the results of molecular dynamics simulations were used in the context of the concept of dynamical self-organization. In the second paper we describe the principles of dynamic self-organization and develop the theory of KcsA channel gating based on this concept. Conclusions. Present work is the first successful attempt of combining the structure and dynamics of real protein and the general concept of dynamic self-organization.
Keywords: ion channel, KcsA channel, dynamic self-organization, channel gating.