Biopolymers and Cell. 2011; 27(4): 249-257
MOLECULAR MECHANISMS OF DEVELOPMENT OF CELLULAR INSULIN RESISTANCE
Raksha N. G., Savchuk O. M., Ostapchenko L. I.
Taras Shevchenko National University of Kyiv
64, Volodymyrska Str., Kyiv, Ukraine, 01601
Some of the pathogenetic mechanisms which cause the state of cellular insulin resistance on receptor and postreceptor levels were analyzed. Special attention is given to the analysis of factors which influence the activity of the components of phosphatidylinositol chain of insulin signaling cascade.
Keywords: insulin resistance, insulin receptor substrates, phosphatidylinositol-3-kinase, serine phosphorylation