Biopolymers and Cell. 2012; 28(4): 288-291

 

MINIATURE AS A HYPOTHETICAL REGULATORY PROTEIN OF THE BURSICON/RICKETS SIGNALING CASCADE IN THE WING EPITHELIA OF DROSOPHILA MELANOGASTER

 

Bilousov O. O., Katanaev V. L., Kozeretska I. A.


1Department of Pharmacology and Toxicology, University of Lausanne
27, Bugnon Str., CH-1005 Lausanne, Switzerland

2Institute of Protein Research, Russian Academy of Sciences
Pushchino, Moscow Region, Russian Federation, 142290

3Educational and Scientific Center «Institute of Biology», National Taras Shevchenko University of Kyiv
64/13, Volodymyrska Str., Kyiv, Ukraine, 01601

Soon after eclosion, epithelial cells of the Drosophila wing undergo a number of the processes due to a release of the neurohormone bursicon and its further binding to the GPCR Rickets, collectively referred to as wing maturation. Here we propose hypothetical models of the interaction between extracellular Miniature, and also Dusky, proteins and proteins responsible for triggering of the wing maturation processes in Drosophila melanogaster.

 


Keywords: bursicon, Rickets, Miniature, Dusky, wing maturation.