Biopolym. Cell. 2007; 23(2):67-85.
Structure-functional characterization of cytochrome P4502E1 (CYP2E1)
1Danko I. M., 1Chaschin N. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


This review summarizes data on expression level and localization, structure and functional properties of cytochrome P4502E1 (CYP2E1). Induction of CYP2E1 synthesis and activity by compounds with various chemical structures and under certain pathophysiological states is considered. Special emphasis is placed on CYP2E1 expression inhibitors. The latest data on CYP2E1 expression regulation and degradation mechanisms are analyze
Keywords: cytochrome P4502E1 (CYP2E1), expression, inductors and inhibitors, expression regulation, oxidative metabolism of ethanol


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