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Genome and Its Regulation
Nuclear RNA at the early stage of liver regeneration
- Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
During the first three hours of the rat liver regeneration two stages differing in synthesis, accumulation and qualitative characteristics of nuclear RNA are observed. At the first stage (0.5–1 h after operation) the synthesis of total and poly (A) + nuclear RNA, transcription of some unique DNA sequences and translocation of newly formed RNA from nucleus to cytoplasm are intensified. At the second stage (1–3 h after partial hepatectomy) the synthesis of total, poly (A) + nuclear RNA as well as transcription of some unique DNA sequences decrease while newly formed RNA is retained in nucleus. Nuclear RNA is characterized by a decrease in complexity of transcripts from unique part of genome with simultaneous increase in the number of some their copies and the growth of diversity of transcripts from middle repetitive sequences and relative content of transcripts from highly repeated DNA.
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