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Structure and Function of Biopolymers
Influence of antiarrhythmic and nootropic drugs on model and biological membranes
- Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine
14, Eugene Pottier Str., Kyiv, Ukraine, 03057
- Zaporizhzhya Medical Institute
Mayakovsky avenue 26, Zaporozhye, Ukraine, 69035
Membranotropic action of antiarrythmic and nootropic drugs (anaprilin, etmozine, carnithine, piracetam, phenhisole, ksantiverine, phenoxanone, compounds E and VS) was studied on lyposomes from lecithine, cardiolypine and synaptosomal membranes of rabbit brain by means of spectrofotometry and spectrofluorometry using fluorescent probes of pyrene. The ability of these compounds to form complexes with lipid bilayer, increase of its motility, was shown. The studied physiologically active compounds decrease calcium-binding properties of synaptosomal membranes and of bilayer from cardiolypine.
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