Biopolym. Cell. 2007; 23(3):155-166.
Современная картина спонтанного мутагенеза и возможное место в ней природной таутомерии оснований ДНК
1Черепенко Е. И., 1Говорун Д. Н.
  1. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03680

Abstract

Cуммированы данные по изучению всевозможных источников спонтанного мутагенеза, определяемого внутриклеточными процессами жизнедеятельности клетки в различных условиях ее функционирования. Охарактеризованы механизмы возникновения подавляющего числа классов мутаций, а также возможные механизмы регуляции скорости спонтанного мутагенеза. Анализ данных значительного повышения пула дНТФ в клетках в условиях генотоксического стресса и соответствующего повышения уровня мутаций в таких клетках позволяет объяснить наблюдаемый результат эффектами таутомерии оснований ДНК, происходящими при столпотворении этих молекул в тесном молекулярном пространстве. Предполагается, что контроль над скоростью спонтанного мутагенеза может быть связан с контролем над концентрацией дНТФ в клетке.
Keywords: спонтанный мутагенез, таутомерия оснований ДНК, уровни внутриклеточного пула дНТФ

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