Biopolym. Cell. 2007; 23(3):172-187.
Мутагенез при интеграционных процессах и эволюция ядерного генома
1Лукаш Л. Л.
  1. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03680

Abstract

Рассмотрены вопросы мутационной изменчивости, вызываемой крупными структурными перестройками генетического материала, такими как транспозиции мобильных генетических элементов, интеграция или дезинтеграция экзогенных нуклеотидных последовательностей вирусной и невирусной природы, изменения хромосомного набора или отдельных хромосом, диминуция хроматина, и роль такой изменчивости в эволюции ядерного генома.
Keywords: мутагенез, эволюция, ядерный геном, гетерохроматин, мобильные генетические элементы, хромосома, диминуция хроматина

References

[1] Kordyum VA. Problem of tumor origin as it is from the molecular genetics point of view. Biopolym Cell. 2001; 17(2):109-39.
[2] Glazko VI. Genetically modified organisms, from bacteria to humans. Kiev: Min of Education and Science of Ukraine. 2002. 210 p.
[3] Zhimulev IF. General and Molecular Genetics. Novosiborsk: Sib. Univ Izd. 2003. 480 p.
[4] Inge-Vechtomov SG. Genetics with basis of breeding: textbook for high school students. M.: Vyshaya Shkola, 1989;290-369.
[5] Gershenson SM. Fundamentals of modern genetics. Kiev: Naukova Dumka. 1983. 240 p.
[6] Gershenson SM. Mutations. Kiev: Naukova Dumka. 1991;111 p.
[7] Zhestyanikov VD. DNA repair and its biological significance. Leningrad, Nauka, 1979. 286 p.
[8] Khesin RB. Genome instability. Moscow, Nauka, 1984; 472 p.
[9] Alekperov UK. Antimutagenesis. Moscow, Nauka, 1984; 100 p.
[10] Cervantes RB, Stringer JR, Shao C, Tischfield JA, Stambrook PJ. Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc Natl Acad Sci U S A. 2002;99(6):3586-90.
[11] Shapiro NI, Varshaver NB. [Rate of the spontaneous mutation process in mammalian somatic cells and several related questions]. Genetika. 1976;12(7):132-49.
[12] Lukash LL. The regulation of a variability of somatic mammalian cell genome under the influence of exogeneous biological factors. Biopolym Cell. 2004; 20(1-2):93-105.
[13] Akif'ev AP. Redundant DNA genetic squaring the circle? Priroda. 2004;10.
[14] Akif'ev AP. Silencing DNA and its role in the evolution. Priroda. 1974;(9):49-54.
[15] Gvozdev VA. Mobile eukaryotic DNA. 2. The role in regulating the activity of genes and genome evolution. Soros Educat J. 1998;(8):15-21.
[16] Ratner VA, Vasileva LA. Induction of mobile genetic elements transposition by stress effects. Soros Educat J. 2000; 6:14-20.
[17] Ratner VA, Vasileva LA. Mobile genetic elements (MGE) and the evolution of genomes. Mobile genetic elements. M Nauka 1993. http://macroevolution.narod.ru/ratner1.htm
[18] Lukash LL. [Destabilization of the cellular genome while expressing early regulatory genes from oncoviruses]. Tsitol Genet. 2002;36(2):68-80.
[19] Lukash LL. Biological mutagens: their impact on the stability of eukaryotic cell systems. Vest Ukr tov genet ta selek. 2003; (1):62-81.
[20] Ageenko AI. Oncogenes and carcinogenesis. M.: Meditsina, 1986; Vol. 256. 152 p.
[21] Popov LS, Gorbunova LV, Varshaver NB, Shapiro NI. [Integration of SV40 DNA into the cell genome and viral mutagenesis]. Genetika. 1986;22(9):2213-9.
[22] Doerfler W. Uptake, fixation, and expression of foreign DNA in mammalian cells: the organization of integrated adenovirus DNA sequences. Curr Top Microbiol Immunol. 1982;101:127-94.
[23] Kuhlmann I, Doerfler W. Loss of viral genomes from hamster tumor cells and nonrandom alterations in patterns of methylation of integrated adenovirus type 12 DNA. J Virol. 1983;47(3):631-6.
[24] Schulz M, Doerfler W. Deletion of cellular DNA at site of viral DNA insertion in the adenovirus type 12-induced mouse tumor CBA-12-1-T. Nucleic Acids Res. 1984;12(12):4959-76.
[25] Lukash SI, Lukash LL, Zadoroznyi VF. Mathematical model of mutagenesis dynamics under the action of adenovirus DNA fragment. Biopolym Cell. 1996;12(3):7-16.
[26] Gazaryan KG. Microinjection of genes in zygotes and embryos: integration into the genome and genetic effects. Usp sovrem Genet. 1985; 13: 75-88.
[27] Tarantul VZ, Kuznetsova ED, Gazarian KG. [Characteristic of segments of transgenic animal genomes, adjacent to integrated sequences of foreign DNA]. Mol Biol (Mosk). 1989;23(4):1036-40.
[28] Nabirochkin SD, Gabitova LB, Begetova TV, Gazarian KG. [Induction of unstable mutations in Drosophila melanogaster by microinjection of oncogenic virus DNA into polar embryonic plasm. Malignant effect of oncoviral DNA]. Genetika. 1991;27(5):783-90.
[29] Gordon JW. A foreign dihydrofolate reductase gene in transgenic mice acts as a dominant mutation. Mol Cell Biol. 1986;6(6):2158-67.
[30] Akifyev AP. Mechanisms of the production of chromosomal aberrations in eukaryotic cells. Physiol General Biol Rev. 1995; 10: 1-56.
[31] Tomilin NV. Genetic stability of the cells. Leningrad: Nauka, 1983. 158 p.
[32] Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME, Rosenfeld MG, Birnberg NC, Evans RM. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature. 1982;300(5893):611-5.
[33] Wilkie TM, Palmiter RD. Analysis of the integrant in MyK-103 transgenic mice in which males fail to transmit the integrant. Mol Cell Biol. 1987;7(5):1646-55.
[34] Harbers K, Kuehn M, Delius H, Jaenisch R. Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice. Proc Natl Acad Sci U S A. 1984;81(5):1504-8.
[35] Hanahan D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature. 1985 May 9-15;315(6015):115-22.
[36] Bobrysheva IV, Baron EM, Varshaver NB. [Plasmid pSVc-myc-1 induces gene mutations and chromosome aberrations in cultured Chinese hamster cells]. Tsitol Genet. 1993;27(4):51-5.
[37] Bobrysheva IV, Varshaver NB. [Characteristics of mutants induced by the c-Ha-ras1 oncogene and the nature of the oncogene's mutagenic action]. Genetika. 1995;31(12):1598-604.
[38] Shakhmuradov IA, Kapitonov VV, Kolchanov NA, Omel'ianchuk LV. [Evolution of Alu repeats: dynamics of distribution in genome]. Genetika. 1989;25(9):1682-9.
[39] Lukash LL, Shvachko LP, Kostetskaya KV. Mobile genetic elements in mutagenic process, recombination and malignization of human cells. Biopolym Cell. 1996; 12(2):7-19.
[40] Rubtsov NB, Borodin PM. Evolution of chromosomes from A to B and back. Priroda. 2002; 3.
[41] Akif'ev AP, Khudoli? GA. [Mutagenesis and genetic homeostasis in higher organisms]. Vestn Ross Akad Med Nauk. 1993;(1):3-9.
[42] Akif'ev AP, Grishanin AK, Degtiarev SV. [Chromatin diminution is a key process explaining the eukaryotic genome size paradox and some mechanisms of genetic isolation]. Genetika. 2002;38(5):595-606.
[43] Grishanin AK, Shekhovtsov AK, Bo?kova TV, Akif'ev AP, Zhimulev IF. [Chromatin diminution at the border of the XX and XXI centuries]. Tsitologiia. 2006;48(5):379-97.