Normal microflora of human skin and the development of its representatives depending on the skin pH are considered in this article. It is shown a possibility of using probiotic microorganisms of genera Bifidobacterium, Lactobacillus, Lactococcus, Bacillus and their metabolites for making the cosmetic medical remedies for different skin types. It was revealed that the probiotic microorganisms’ lysates contain a large amount of biologically active substances that contribute to the recovery of the skin epidermis and inhibit the development of pathogenic skin microflora.