Biopolym. Cell. 2025; 41(4):292.
http://dx.doi.org/10.7124/bc.000B1E
Bioorganic Chemistry
Synthesis and antifungal activity of 3-oxo-2-piperazinylacetamides
1Borovykov O. V., 1Lukashov S. S., 2Drapailo A. B., 1Tarnavskiy S. S., 3Bieda O. A., 1Yarmoliuk S. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143
  2. Institute of Organic Chemistry, NAS of Ukraine
    5, Akademika Kuharya Str., 5, Kyiv, Ukraine, 02094
  3. LLC «Scientific and service firm “Otava”»
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143

Abstract

Aim. Synthesis of 3-oxo-2-piperazinylacetamides and investigation of their antifungal activity. Methods. Organic synthesis, spectral methods (NMR), pharmaceutical screening. Results. A series of new 3-oxo-2-piperazinylacetamides has been synthesized and the screening of their antifungal activity was performed. N-butyl-3-oxo-2-piperazineacetamide shows antifungal activity against Cryptococcus neoformans comparable with amphotericin B and fluconazole (MIC = 2μg/mL). Conclusions. 3-oxo-2-piperazineacetamide moiety has been identified as a promising template to search for novel antimicrobials against Cryptococcus neoformans.
Keywords: 3-oxo-2-piperazinylacetamides, N-butyl-3-oxo-2-piperazinylacetamide, antifungal activity, Cryptococcus neoformans
Full text: (PDF, in English)

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