Biopolym. Cell. 1993; 9(3):17-22.
http://dx.doi.org/10.7124/bc.000355
Structure and Function of Biopolymers
The investigation of interactions of hypoxanthine, xanthine and their methyl and glycosyl derivatives with amino acid carboxylic group by spectroscopic methods
1Zheltovsky N. V., 1Samiylenko S. P., 1Kolomiets I. N., 1Kondratyuk I. V., 1Stepanyugin A. V.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

The interactions of some methyl and glycosyl derivatives of hypo-xanthine and xanthine with ionized and neutral amino acid carboxylic group were investigated in dimethylsulfoxide. It was established that ionized carboxylic group forms complexes with hypoxanthine, inosine, xanthine, 3-methylxanthine and 9-methylxanthine. In the last case the proton transfer occurs from the base to carboxylate-ion. The methylation of hypoxanthine and xanthine nucleosides at N7 atoms results in their ability to interact with a neutral carboxylic group. The weak interaction with neutral carboxylic group was observed in the case of 9,-methylxanthine. 1-Methylxanthine proved to be indifferent to the two forms of carboxylic group.
Full text: (PDF, in Russian)

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