Biopolym. Cell. 2003; 19(2):113-132.
Дискусії
Наша «шагренева шкіра» — це наша проблема. Нам її і вирішувати
1Кордюм В. А.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Розкриття комплексу механізмів, що обумовлюють абсолют­ну надійність обмеженості часу індивідуального життя будь-якого організму (в тому числі і людини) при майже такій самій надійності існування практично безсмертного життя у вигляді безперервного ланцюга безумовно смертних поколінь, сьогодні входить до переліку проблем, які підлягають вирі­шенню сучасною біологією. У запланованій серії з чотирьох публікацій формулюються уявлення, на основі яких буде зроб­лено спробу побудувати концепцію цієї проблеми. В першій публікації аналізуються матеріали, що дозволяють вважати клітину типовою (хоча й дуже складною та бездоганною) молекулярною машиною, а організм — системою таких моле­кулярних машин, які самоорганізуються.

References

[1] Lugowski W, Lombardo RG. Biogenetyka i jei Krytycy. Kosmos. 1990; 39(2-3): 207-18.
[2] Ridley M. The search for LUCA. Natur Hist. 2000; 109(9):82-5.
[3] Schopf JW. Deep divisions in the Tree of Life--what does the fossil record reveal? Biol Bull. 1999;196(3):351-3; discussion 354-5.
[4] Schindelhauer D. Construction of mammalian artificial chromosomes: prospects for defining an optimal centromere. Bioessays. 1999;21(1):76-83.
[5] Nilsen TW. The case for an RNA enzyme. Nature. 2000;408(6814):782-3.
[6] King MP, Attardi G. Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA. Cell. 1988;52(6):811-9.
[7] Nikitin VA, Fesenko EE. Modern technology of cloning cells and mammalian organisms: Abstracts of the reports. Proc. Symposium. "Cell Biology in the XXI Century" (Saint Petersburg, 17-19 Oct, 2000). Tsitologiia. 2001; 41(4):371-2.
[8] Hamari Zs, Juhasz A, Kevei F. Incompatibility influences the effectivity of mitochondrial transmission: Abstr. 1 Joint Meet. Sloven. Soc. Microbiol, and the Hung. Soc. Microbiol. (Keszthely, Aug. 24-26, 2000). Acta microbiol immunol huhg. 2001; 48(2):170-1.
[9] Cho MK, Magnus D, Caplan AL, McGee D. Policy forum: genetics. Ethical considerations in synthesizing a minimal genome. Science. 1999;286(5447):2087, 2089-90.
[10] Kordyum VA. The origin of life and its first steps allowing for the matrix synthesis. Molekulyarnaia Biologiia (Kiev). 1980; (30):76-85.
[11] Kordyum VA. About a conception of viruses and their place in the biosphere. Biopolym Cell. 2000; 16(2):87-98.
[12] Heinemann JA, Sprague GF Jr. Bacterial conjugative plasmids mobilize DNA transfer between bacteria and yeast. Nature. 1989;340(6230):205-9.
[13] Sikorski RS, Michaud W, Levin HL, Boeke JD, Hieter P. Trans-kingdom promiscuity. Nature. 1990;345(6276):581-2.
[14] Doolittle WF. Lateral genomics. Trends Cell Biol. 1999;9(12):M5-8.
[15] Doolittle WF. Uprooting the tree of life. Sci Am. 2000;282(2):90-5.
[16] Blau HM, Brazelton TR, Weimann JM. The evolving concept of a stem cell: entity or function? Cell. 2001;105(7):829-41.
[17] Broda E. The Evolution of Bioenergetic Processes, Pergamon, Oxford, 1975. 220 p.
[18] Dean RT. Cellular degradative processes (Outline studies in biology). Wiley, 1978.
[19] Cruz-Coke R. A general diagram of the human genome. J Med Genet. 1990;27(6):388-9.
[20] Johnson FB, Sinclair DA, Guarente L. Molecular biology of aging. Cell. 1999;96(2):291-302.
[21] Pagel M, Johnstone RA. Variation across species in the size of the nuclear genome supports the junk-DNA explanation for the C-value paradox. Proc Biol Sci. 1992;249(1325):119-24.
[22] Escribano R, McLaren IA, Breteler WCMK. Innate and acquired variation of nuclear DNA contents of marine copepods. Genome. 1992;35(4):602–10.
[23] Th?mmes P, H?bscher U. Eukaryotic DNA replication. Enzymes and proteins acting at the fork. Eur J Biochem. 1990;194(3):699-712.
[24] Echols H, Goodman MF. Fidelity mechanisms in DNA replication. Annu Rev Biochem. 1991;60:477-511.
[25] Vilenchik MM. Biological basis of aging and longevity. 1987. Moscow, Znanie. 189 p.
[26] Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A. 1988;85(17):6465-7.
[27] Malvy C, Lefran?ois M, Bertrand JR, Markovits J. Modified alkaline elution allows the measurement of intact apurinic sites in mammalian genomic DNA. Biochimie. 2000;82(8):717-21.
[28] Park JW, Ames BN. 7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection. Proc Natl Acad Sci U S A. 1988;85(20):7467-70.
[29] Jendryczko A, Drozds M. Podstawowy poziom uszkodzen DNA komorek ludzkich. Poz. Lek. 1989; 46(5): 470-3.
[30] Delehanty J, White RL, Mendelsohn ML. International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Meeting Report No. 2. Approaches to determining mutation rates in human DNA. Mutat Res. 1986;167(3):215-32.
[31] Giphart-Gassler M, Groenewegen A, den Dulk H, van de Putte P, Tasseron-de Jong JG. Studying DNA mutations in human cells with the use of an integrated HSV thymidine kinase target gene. Mutat Res. 1989;214(2):223-32.
[32] Morley A. Comparison of hprt and HLA-A mutations. Mutat Res. 1989. 216(l): 72.
[33] Tates AD, Rossi AM, Natarajan AT. Detection of hprt? mutants in human T-lymphocytes and mouse splenocytes. Mutat Res. 1989;216(1):83-4.
[34] Harrington-Brock K, Cabrera M, Collard DD, Doerr CL, McConnell R, Moore MM, Sandoval H, Fuscoe JC. Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile: a pilot study. Mutat Res. 1999;431(2):247-57.
[35] Bigbee WL, Day RD, Grant SG, Keohavong P, Xi L, Zhang L, Ness RB. Impact of maternal lifestyle factors on newborn HPRT mutant frequencies and molecular spectrum--initial results from the Prenatal Exposures and Preeclampsia Prevention (PEPP) Study. Mutat Res. 1999;431(2):279-89.
[36] Davies MJ, Turner JG, Vives-Bauza C, Rumsby PC. Investigation of mutant frequency at the HPRT locus and changes in microsatellite sequences in healthy young adults. Mutat Res. 1999;431(2):317-23.
[37] Groden J, Nakamura Y, German J. Molecular evidence that homologous recombination occurs in proliferating human somatic cells. Proc Natl Acad Sci U S A. 1990;87(11):4315-9.
[38] Rudd C, Daston D, Carpary WJ. Spontaneous mutation rates in mammalian cells: Effect of differential growth rates and phenotypic lag. J Cell Biochem. 1991; Suppl. 15D:119.
[39] Kordyum VA. And then I sat down to write this book: It is not usual notions of human genetics. Kiev, 1993; 248 p.
[40] Grujicic D, Milosevic O, Marinkovic D, Arsenjevic S, Bankovic S, Zivanovic A, Dimitrijevic A. Effect of gestagens on micronucleus frequency in human peripheral blood lymphocytes. Balkan J Med Genet. 1999. 2(2): 23-8.
[41] Yadav JS, Seth N. Effect of diagnostic X-rays on somatic chromosomes of occupationally exposed workers. Indian J Exp Biol. 2000;38(1):46-50.
[42] Druzhinin VG, Minina VI, Mokrushina NV. [Cytogenetic disorders in workers of coal-tar chemical industry]. Med Tr Prom Ekol. 2000;(10):22-4.
[43] Bochkov NP, Chebotarev AN, Katosova LD, Platonova VI. [The database for analysis of quantitative characteristics of chromosome aberration frequencies in the culture of human peripheral blood lymphocytes]. Genetika. 2001;37(4):549-57.
[44] Wyrobek A, Currie M, Stilwell JL, Balhorn R, Stanker LH. Detecting specific-locus mutations in human sperm. Biol. Mammal. Germ. Cell Mutagenesis: Abstr. conf. New York: Cold Spring Harbor Lab. publ., 1990: 109-11.
[45] Mikamo K, Kamiguchi Y, Tateno H. Spontaneous and in vitro radiation-induced chromosome aberrations in human spermatozoa: application of a new method. Environ Mol Mutagen. 1989; 14, Suppl: 129.
[46] Martin R. Chromosomal analysis of human spermatozoa. Preimplantant. Genet.: Proc. 1st Int. Symp. (Chicago, III, Sept. 14-19, 1990). New York; London, 1991: 91-102.
[47] Pellestor F. Frequency and distribution of aneuploidy in human female gametes. Hum Genet. 1991;86(3):283-8.
[48] Paiva W, Jose M, Satorelli EMP, Tepmlado C, de Pina-Neto JM. The chromosomal constitution of spermatozoa from eight normal, healthy Brazilian men. Med Fac Med Ribeirao Preto Hosp Clin. 1999; 32(2): 199-202.
[49] Jeffreys AJ, Royle NJ, Wilson V, Wong Z. Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA. Nature. 1988;332(6161):278-81.
[50] Foutdevila A. The unstable genome: an evolutionary approach. Genetics. 1987; 39, (3-4):315-43.
[51] Arnault C, Heizmann A, Loevenbruck C, Bi?mont C. Environmental stresses and mobilization of transposable elements in inbred lines of Drosophila melanogaster. Mutat Res. 1991;248(1):51-60.
[52] Heidmann O, Heidmann T. Retrotransposition of a mouse IAP sequence tagged with an indicator gene. Cell. 1991;64(1):159-70.
[53] Ratner VA, Zabanov SA, Kolesnikova OV, Vasilyeva LA. Induction of the mobile genetic element Dm-412 transpositions in the Drosophila genome by heat shock treatment. Proc Natl Acad Sci U S A. 1992;89(12):5650-4.
[54] Prolla TA. DNA mismatch repair and cancer. Curr Opin Cell Biol. 1998;10(3):311-6.
[55] Radman M. Enzymes of evolutionary change. Nature. 1999;401(6756):866-7, 869.
[56] Zhestianikov VD. [Non-mutagenic and mutagenic post-replicative DNA repair in prokaryotic and eukaryotic cells]. Tsitologiia. 2000;42(9):837-43.
[57] Johnson RE, Prakash S, Prakash L. The human DINB1 gene encodes the DNA polymerase Poltheta. Proc Natl Acad Sci U S A. 2000;97(8):3838-43.
[58] Mezhevaya K, Winters TA, Neumann RD. Gene targeted DNA double-strand break induction by (125)I-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells. Nucleic Acids Res. 1999;27(21):4282-90.
[59] Jackson AL, Loeb LA. The mutation rate and cancer. Genetics. 1998;148(4):1483-90.