Biopolym. Cell. 2013; 29(3):207-214.
Огляди
Сигнальний шлях PI3K/mTOR/S6K – нові гравці та нові функціональні зв’язки
1Філоненко В. В.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

В огляді представлено експериментальні результати дослідження сигнального шляху PI3K/mTOR/S6K, отримані у відділі сигнальних систем клітини. Аналіз нещодавно виявлених білково-білкових взаємодій S6K надає важливу інформацію для розуміння молекулярних механізмів регуляції функціональної активності S6K та її субклітинної локалізації за участі PKC, CK2 і убіквитинлігази ROC1. Обговорюються дані щодо ідентифікації і функціонального аналізу нової ізоформи кінази рибосомного білка S6 – S6К2 і mTOR- кінази – mTOR, а також їхніх онкогенних властивостей. Ідентифікація CoA-синтази, що є відповідальною за два останніх етапи біосинтезу CoA, а також характеристика її взаємодії з S6K1 та іншими сигнальними молекулами свідчать про існування потенційного зв’язку між сигнальним шляхом mTOR/S6K та енергетичним метаболізмом, опосередкованого регуляцією біосинтезу CoA. Наведено дані стосовно виявлених молекулярних механізмів регуляції активності синтази СоА.
Keywords: PI3K/mTOR/S6K, сигнальні системи клітини, білково-білкові взаємодії, кіназа S6, синтаза CoA

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