Biopolym. Cell. 2013; 29(4):283-294.
Огляди
Регуляція мутагенезу екзогенними біологічними чинниками в евкаріотних клітинних системах
1Лукаш Л. Л.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Проаналізовано уявлення щодо природи мутацій і спонтанного мутаційного процесу, а також мутагенезу, індукованого екзогенними онковірусами, ДНК і білками-мітогенами. Екзогенні біологічні чинники індукують пошкодження ДНК регуляторно-інформаційним шляхом, діючи на системи підтримки генетичної стабільності. Молекулярні механізми мутацій такі самі, як і за спонтанного мутагенезу, але реалізуються за участі чужорідного генетичного матеріалу. Серед біогенних мутагенів виокремлюють онковіруси і мобільні генетичні елементи (МГЕ) як найсильніші дестабілізувальні фактори, що контролюють процес злоякісної трансформації соматичних клітин ссавців. Генетичне перепрограмування або зміна програм генної експресії при диференціюванні стовбурових клітин і клітин-попередників під впливом ростових факторів и цитокінів, ймовірно, також супроводжується мутаціями й рекомбінаціями.
Keywords: мутагенез, мутація, клітини евкаріотів, онковіруси, МГЕ, білок-мітоген

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