Biopolym. Cell. 2017; 33(2):81-91.
http://dx.doi.org/10.7124/bc.000946
Огляди
Залежність персистентної довжини ДНК від іонних умов
1Зарудна М. І., 1Потягайло А. Л., 1Говорун Д. М.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Функціонування ДНК включає як значне стиснення при утворенні хроматину або пакуванні у вірусні частинки, так і утворення петель при контролі генної експресії. Персистентна довжина (Р), що характеризує жорсткість дволанцюгової ДНК на вигинання, має безпосереднє відношення до цих процесів. Незважаючи на численні експериментальні та теоретичні дослідження персистентної довжини, загальна думка про характер її залежності від концентрації солі нині так і не визріла – немає чіткого розуміння природи фундаментальних сил, які обумовлюють жорсткість ДНК. В даному короткому огляді ми наводимо на основі літературних даних узагальнену залежність персистентної довжини ДНК від концентрації солі і обговорюємо вплив на неї різних факторів. Зокрема, ми обговорюємо структурні особливості G- та А-трактів ДНК.
Keywords: ДНК, персистентна довжина, ефективний діаметр, G-тракти, A-тракти
Повний текст: (PDF, англійською)

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