Biopolym. Cell. 2017; 33(5):323-334.
http://dx.doi.org/10.7124/bc.000957
Огляди
Оксид азоту як основний поліфункціональний регулятор імунокомпетентних та ендотеліальних клітин
1Садляк О. В., 1Байда М. Л., 1Колішецька М. А., 1Мусій-Семенців Х. Г., 1Семенців Н. Г., 1Лесик Р. Б.
  1. Львівський національний медичний університет імені Данила Галицького
    вул. Пекарська, 69, Львів, Україна, 79010

Abstract

Сьогодні важко визначити функцію організму у якій би не брав участь оксид азоту (NO), а це означає, що в принципі кожна тканина органу знаходиться під впливом змінених концентрацій оксиду азоту та його метаболітів. В огляді проводиться аналіз фенотипічних ефектів NO та його метаболітів в макрофагах, NK-клітинах, лімфоцитах, які забезпечують захист організму-“хазяїна“ від злоякісних новоутворень і патогенів, а за умов порушення його синтезу можуть ініціювати дисбаланс в імунній системі. Також обговорюється важлива роль оксиду азоту у розвитку ендотеліальної дисфункції – процесах пригнічення агрегації і адгезії тромбоцитів, порушеннях вазодилатації і вазоконстрикції судин, змін реологічних властивостей крові та розвитку атеросклеротичних бляшок. Тому дисбаланс в синтезі оксиду азоту, опосередкований змінами судинного ендотелію, може бути раннім маркером розвитку патологій різного генезу.
Keywords: NO-синтази, лімфоцити, імунна система, запалення, eндотеліальна дисфункція, ендотеліоцити
Повний текст: (PDF, англійською)

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